Colony growth of peripheral blood cells from patients with acute lymphocytic leukemia.
نویسندگان
چکیده
The colony-forming potential of peripheral blood cells from ten patients with acute lymphocytic leukemia, as well as their urinary colony-stimulating activity levels, has been studied. Peripheral white blood cells from 4 of 10 patients with acute lymphocytic leukemia formed significant numbers of colonies when grown on feeder layers of normal human white blood cells. The colonies were composed of peroxidase-positive cells with lobulated nuclei. Urinary colony-stimulating activity levels were variable and appeared to be related to the total absolute granulocyte count in both treated and untreated patients.
منابع مشابه
Advances in Hematopoietic Stem Cell Mobilization and Peripheral Blood Stem Cell Transplantation
Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interacting factors such as stromal derived factor-1/CXCR4, very late antigen-4/vascular cell adhesion molecule-1, Lymphocyte function-associated antigen-1/ intercellular adhesion molec...
متن کاملCD4+ T Cells are Exhausted and Show Functional Defects in Chronic Lymphocytic Leukemia
Background: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. This health problem is caused due to the accumulation of mature B-lymphocytes in the peripheral blood and bone marrow. In the course of cancer, CD4+ T cells become “exhausted” and characterized with poor effector functions and the expression of multiple inhibitory receptors. Objective: To inve...
متن کاملالگوریتم بهینه تقسیمبندی تصاویر میکروسکوپی خون برای تشخیص سلولهای لوسمی حاد لنفوبلاست با استفاده از الگوریتم FCM و بهینهسازی ژنتیک
Cancer is type of disease caused by irregular, uncontrollable growth of blood cells in bone marrow. The process of generating three main blood cells including pallets, red and white blood cells, is started from a progenitor cell called as blast. Blast generates a considerable number of immature cells which are developed affected by differentiation factors. If any interruption occurs during this...
متن کاملExpression Profile of Wnt Molecules in Leukemic Cells from Iranian Patients with Acute Myeloblastic Leukemia
Background: Wnt molecules play a key role in growth, proliferation and development of some embryonic and adult organs as well as hematopoietic stem cells. Wnt signaling pathways are aberrantly activated in many tumor types, including solid tumors and hematologic malignancies. Objective: To investigate the expression profile of a large number of Wnt genes in leukemic cells from Iranian patients ...
متن کاملEffect of curcumin on growth inhibition and gene expression reduction in chronic lymphocytic leukemia cells (CLL-CII)
Introduction: Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults living in Western countries. with a diverse clinical course that due to life expectancy less than two years between patients finding ,new therapeutic strategies is essential for it. Curcumin as the biologic active of turmeric, has many biological properties such as anti-inflammatory, anti-oxidant, anti-diab...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer research
دوره 32 10 شماره
صفحات -
تاریخ انتشار 1972